![]() Recent improvements in the understanding of pathological features have changed the categorizations of inflammatory myopathies that were previously simply known as polymyositis, dermatomyositis, and inclusion-body myositis. ![]() Furthermore, knowledge of the muscle pathology becomes more valuable when inflammatory myopathy is suspected. ![]() However, clinical and pathological information is still needed to distinguish true pathogenic variations from the huge amount of genetic data. Recent developments in next generation sequencing have led to genetic tests being directly applied to more cases of inherited myopathies, because whole exome sequencing or myopathy gene panel sequencing makes a genetic diagnosis easier by providing broad genetic data. Genetic testing can sometimes replace a muscle biopsy, such as when the clinical features are sufficiently characteristic of a specific diagnosis, including myotonic dystrophy and facioscapulohumeral muscular dystrophy. However, it should be remembered that such findings are not always specific to a particular disease, and can actually confuse the diagnosis in many cases. The principal findings include muscle fiber atrophy and hypertrophy, necrosis and regeneration, inflammatory infiltration, and abnormal inclusions within muscle fibers. Muscle pathology findings can provide a considerable amount of information about the pathological processes causing muscle weakness. ![]()
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